Lars Herfindal Selected Research

iodinin

4/2021	New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells.
1/2017	Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives.
1/2013	Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells.

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Lars Herfindal Research Topics

Disease

13	Neoplasms (Cancer) 10/2021 - 09/2009
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2021 - 10/2010
4	Leukemia 01/2017 - 10/2010
2	Hypoxia (Hypoxemia) 04/2021 - 01/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2021
1	Breast Neoplasms (Breast Cancer) 11/2020
1	Brain Neoplasms (Brain Tumor) 01/2020
1	Glioblastoma (Glioblastoma Multiforme) 01/2020
1	Fibrosis (Cirrhosis) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2018
1	Neurologic Manifestations (Neurological Manifestations) 01/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2018
1	Cardiotoxicity 01/2016
1	Myeloid Leukemia (Leukemia, Myelocytic) 01/2013
1	T-Cell Lymphoma (Lymphoma, T Cell) 04/2011
1	Poisoning 07/2010
1	Chromosome Aberrations (Chromosome Abnormalities) 02/2002

Drug/Important Bio-Agent (IBA)

6	Pharmaceutical PreparationsIBA 09/2021 - 10/2010
3	iodininIBA 04/2021 - 01/2013
2	myxinIBA 04/2021 - 01/2017
2	OxidesIBA 04/2021 - 01/2017
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2013
2	Liposomes (Liposome)IBA 01/2016 - 01/2016
2	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2013 - 10/2010
1	Peptides (Polypeptides)IBA 10/2021
1	Phenformin (Fenformin)IBA 09/2021
1	Drug CarriersIBA 09/2021
1	GraphiteIBA 09/2021
1	phenazine di-N-oxideIBA 04/2021
1	ProdrugsIBA 04/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2020
1	Antipsychotic Agents (Antipsychotics)IBA 06/2020
1	Chlorpromazine (Thorazine)FDA Link 06/2020
1	Temozolomide (Temodar)FDA LinkGeneric 01/2020
1	Bortezomib (Velcade)FDA Link 01/2020
1	MethyltransferasesIBA 01/2020
1	CytochromesIBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Cytotoxins (Cytolysins)IBA 01/2019
1	Dopamine (Intropin)FDA LinkGeneric 01/2018
1	Oxygen (Dioxygen)IBA 01/2017
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2016
1	Polystyrenes (Polystyrene)IBA 01/2016
1	AnthracyclinesIBA 01/2016
1	Antineoplastic Agents (Antineoplastics)IBA 01/2016
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 10/2015
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 10/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2015
1	Cyclic NucleotidesIBA 01/2014
1	NucleotidesIBA 01/2014
1	Cyclic PeptidesIBA 04/2011
1	microcystinIBA 04/2011
1	MicrocystinsIBA 07/2010
1	EstersIBA 09/2009
1	Cytarabine (Cytosar-U)FDA LinkGeneric 02/2002

Therapy/Procedure

4	Therapeutics 10/2021 - 01/2013
1	Transplantation 11/2020
1	Combined Modality Therapy 01/2020
1	Enzyme Replacement Therapy 01/2018
1	Aftercare (After-Treatment) 02/2002